General description
This support is an excellent tool for the production of C-terminal secondary amides. Primary amines can be loaded onto the resin by reductive amination. Following standard Fmoc SPPS, treatment with TFA releases the peptide secondary amides.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application
Structural and functional cell and organelle mimics: Utilizes FMPB AM resin in the solid-phase peptide synthesis for specific functionalities in cell and organelle mimics, detailing the chemical modification processes involved. (RJRW Peters, 2015).

Linkage
Replaces: 01-64-0209

Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of sulfur after derivatization with tosylhydrazide): 0.80 – 1.10 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene – 1% DVB), 100 – 200 mesh

Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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